Syllabus of Jawaharlal Nehru University MSc Biotechnology - BT516 - Immunology

Credits: 2

A. The Immune System

1. Innate Immune response and its role in protection

2. Adaptive Immune response The humoral and cellular component of the Immune response, Overlap between Innate and adaptive immunity.

3. Cells involved in the Immune response The lymphoid organs, their interaction

B. The antigens seen by the Immune System

1. Antigenicity and Immunogenicity

2. The epitopes seen by B Cells and T Cells

3. Antigen engineering-Increasing Immunogenicity

C. Antibody Molecule

1. Structure of antibody molecules

2. Function of antibody molecules

3. Antibody Antigen interactions

4. Generation of antibody diversity

5. Antibody engineering
-Hybridoma secreting monoclonal antibodies
-Recombinant antibody molecules

D. Major Histocompatibility Complex

1. MHC molecules and organisation of their genes

2. Structure and function of MHC gene products

E. Antigen Presentation

1. Antigen processing

2. Role of MHC and non-MHC molecules
In antigen presentation

F. T Cell receptor

1. αβ T cells

2. γδ T cells

3. TCR-CD complex

4. Structure of TCR and its interaction With MHC-I and MHC-II peptide Complex - T cell selection

5. Organization of TCR gene segments And their rearrangement

G. Activation of T cells

1. Activation TH and TC cells

2. Generation of T memory cells

3. Apoptosis in T cells

H. B Cell matuvation

1. Activation of B Cells

2. Regulation of B Cell mediated
Effector functions

I. Cytokines

1. Structure of Cytokines

2. Cytokine receptors

3. Function of Cytokines

J. The Complement System

K. Cell mediated effector responses