UNIVERSITY OF MADRAS
B.Sc. DEGREE COURSE IN Zoology
SEMESTER SYSTEM WITH CREDITS
(Effective from the Academic Year 2003-2004)

SYLLABUS

Semester V - Paper VI - Genetics

Duration of Examination: 3 hrs
Maximum Marks: 100
Credits: 4

Unit I

Introduction to Genetics - Basis of Mendelian Inheritance and Mendelian Laws. Simple Problems Relating to Inheritance. Structure of Gene - Interaction of Gene - Commentary Factors, Supplementary Factors, Inhibitory and Lethal Factors - Atavism.

Unit II

Blood Groups and their Inheritance in Human - Linkage and Crossing Over:- Drosophila - Morgans' Experiments - Complete and Incomplete Linkage, Linkage Groups, Crossing Over types, Mechanisms - Cytological Evidence for Crossing Over, Mapping of Chromosomes - Interference and Coincidence.

Unit III

Sex Linkage in Drosopohila and Man, Sex Influenced and Sex Limited Genes - Non-Disjunction and Gynandromorphs - Cytoplasmic Inheritance - Maternal Effect On Limnaea (Shell Coiling), Male Sterility (Rode's Experiment). CO₂ sensitivity In Drosophila, Kappa particles in Paramecium, Milk Factor in Mice.

Unit IV

Nature and Function of Genetic Material - Fine Structure of the Gene - Cistron, Recon, Muton - Gene Regulation - Operon Concept - Lac Operon - Positive and Negative Regulation. Mutation - Molecular Basis of Mutation, Types of Mutation, Mutagens, Mutable and Mutator Genes. Chromosomal Aberrations - Numerical and Structural Examples from Human.

Unit V

Applied Genetics - Animal Breeding - Heterosis, Inbreeding, Out Breeding, Out Crossing, Hybrid Vigour. Population Genetics, Hardy Weinberg Law - Gene Frequency, Factors Affecting Gene Frequency, Eugenics, Euphenics and Euthenics, Bioethics.

REFERENCE:

1. Verma, P.S. and V. K.Agarwal, 1995. Genetics, 8^th edition, S.Chand & co., New Delhi - 110 055, 580 pp.

2. Gunther, S. Stent, 1986. Molecular Genetics. Macmillan Publishing Co Inc.

3. Goodenough,V., 1978. Genetics, 2^nded., NewYork Holt, Rinchart and Winston. 894 pp

4. Hartl, D.L. and D. Freifelder, 1988. Basic Genetics, John & Barlett Publishers, 505 pp

5. Gardner, 1972. Principles of Genetics, Wiley Eastern Pvt. Ltd. 590 pp.

6. Watson. J.D. and W.A. Benjamin, 1976. Molecular Biology of the Gene, 3^rd, Benjamin Co. Inc., New York, 739 pp

7. Winchester, 1967. Genetics, Oxford IBH Publications. 504 pp.

8. Stickberger, 1968. Genetics, Macmillan Publications, New York, 914 pp.

9. Pai, A.C, 1974. Foundations of Genetics, McGraw Hill Publications, New York, pp

10. Weaver Robert and Brown, William C, 1996. Genetics, Tata McGraw Hill Publishing Co Ltd., New Delhi, 656 pp

11. BUL corge, W. (New edition) - The Science of Genetics.

12. Concept of Genetics, Human genetics & Eugenics - P.S. Verma & V.K.Agarwal - S.Chand & Company - 1999