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UNIVERSITY OF MADRAS
B.Sc. DEGREE COURSE IN BIO-CHEMISTRY
SEMESTER SYSTEM WITH CREDITS
(Effective from the Academic Year 2003-2004)
SYLLABUS
Semester V - Paper VIII - Molecular Biology II
Duration: 3 hrs
Maximum Marks: 100
Credits: 4
Unit I
Transcription-Prokaryotic RNA polymerase-Enzyme structure, role of sigma factor, promotor, closed and open promoter complexes.
Initiation, elongation and termination of RNA synthesis. (12 hrs)Unit II
Eukaryotic RNA polymerases- I,II,III.
Post transcriptional modification in Prokaryotes. Post transcriptional modifications of mRNA,rRNA and tRNA. Inhibitors of transcription. (12 hrs)
Unit III
Genetic Code-Genetic Code: Basic features of genetic code. Deciphering of Genetic code. Wobble Hypothesis. (12 hrs)
Unit IV
Protein biosynthesis-activation of amino acids, initiation, elongation and termination of Translation in prokaryotes.
Post translation modifications. Inhibitors of translation. (12 hrs)
Unit V
Regulation of gene expression in prokaryotes Operon- Concept- Positive and negative regulation of lac operon. (12 hrs)
BOOKS RECOMMENDED
1. Biochemistry of nucleic acids- Adam et alBusiness Schools - Engineering Colleges - Medical & Nursing Admissions - BEd in Distance mode - Journalism & Media Studies - Forensic Science
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