UNIVERSITY OF MADRAS
B.Sc. Degree Course in Clinical Nutrition and Dietetics
SEMESTER SYSTEM WITH CREDITS
(Effective from the Academic Year 2003-2004)

SYLLABUS

Semester III - Paper VI - Nutritional Bio-Chemistry

Number of Lectures: 4
Duration of Examination: 3 hrs
Teaching/Practical Hours Per Week: Theory: 3 hrs/Week
Maximum Marks: 100
Credits: 4

Theory - 6 hrs. / week

Objectives:

1. To gain an understanding of the applications of Bio-chemistry to food, Nutrition and diet therapy.

Course Content

1. Molecular aspect of transport, passive diffusion, facilitated diffusion, active transport, nutrients and energy needs coupled reactions. No. of Lectures: (2)

2. Biological Oxidation-Electron transport mechanism, NADH dehydrogenase, Cytochromes, electron transport chain, oxidative phosphorylation, energy conservation, high energy phosphate bond, storage and release of high energy phosphate, myokinase reaction. No. of Lectures: (4)

3. Genetic control of Metabolism, Nucleic acid components, structure, replication, RNA components, types, structure, replication, genetic repair mechanism. Genetic code-protein biosynthesis. Viruses and recombinant DNA and bioengineering, Essential pentosuria, fructosuria, galactosemia, gout-nucleic acid metabolism, PKU, Alkaptonuria, Albinism, Aminoaciduria. No. of Lectures: (6)

4. Major Metabolic Pathways: No. of Lectures: (6)

a) Carbohydrates: Review of digestion, absorption and metabolism of carbohydrates anaerobic and aerobic pathways, glycolysis, citric acid cycle, glyconeogenesis, pentose-phosphate pathway, glycogenesis, glyco genolysis, glucose transport, metabolism of lactate and pyruvate.

b) Lipid Metabolism-Review of digestion, absorption an intestinal resynthesis of the glyecrides, metabolism of fats and fatty acids, Beta-oxidation of fatty acids biosynthesis of fatty acids, energy yield from dietary fats, storage, mobilisation of fat stores during exercise, production of ketone bodies and ketogenic diets, metabolism of phospholipids, glycolipids and cholesterol (in brief)

c) Amino acid metabolism: Digestion, absorption, transport, general pathways of Amino acid metabolism, Deaminakion, Transamination, Transdeamination, decarb oxylation, disposal of ammonia, urea cycle-disposal of carbon skeleton of amino acid.

5. Hormones-Pituitary, adrenocortical, thyroid and reproductive hormones-hormones of the adreno cortex-mode of action, prostaglandins, control of homeostasis. No. of Lectures: (3)

6. Acid Base Balance-Buffer system-Renal mechanism, Respiratory mechanism- Disturbance in Acid Base - Balance. No. of Lectures: (3)

7. Energy - BMR, energy requirements for physical activity, relative body weights and influence of physical exercise on changes in body fat and body composition, utilisation of energy by muscle tissue, shifts in lipid and carbo-hydrate, utilization in relation to exercise type, intensity & duration. No. of Lectures: (5)

REFERENCES:

1. Rao K.R. -1986 Textbook of Bio-chemistry, III ed. Prentice Hall of India Pvt. Ltd. ND - 110 001.

2. Murray R.K., V.W. Rodwell-1988 "Harper's Bio-chemistry 21^st Ed. Prentice Hall of Australia Pvt. Ltd.

3. Lehninger, A.L. - 1987 Principles of Bio-chemistry, CBS, Publishers and Distribution.

4. J.M. Qrten & OW. Neuhans 1982, Human Bio-chemistry, The C.V. Mosby Co., Toronto, London, 10^th Ed.

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