MODEL PAPER

B. Tech (CSE) Degree Examination

Forth Year - Second Semester

BIOINFORMATICS (ELECTIVE-II)

Effective from the admitted batch of 2004-2005

Time: 3 hrs
Max Marks: 70

First Question is Compulsory

Answer any four from the remaining questions

All Questions carry equal marks

Answer all parts of any question at one place

1. Explain the following:
a) Folding Problem
b) Motifs
c) UniGene
d) Positional Cloning
e) Identity and Similarity
f) Consensus
g) Hidden Markov Models

2. a) What is broinformatics? Explain the importance of bioinformatics?
b) What are the application areas of different analysts methods?

3. a) Explain the structuze of SWISS-PROT entries.
b) Why create secondary databases?

4. a) Explain GenBank.
b) What is the importance of specialized genomic resources?

5. What is GenBank? Explain the structure of GenBank entries

6. a) Explain Central Dogma of Molecular biology with neat diagram.
b) Describe features of DNA sequence analysis

7. a) Write about BL4ST (Basic Local Alignment Search Tool)
b) Explain the Needleman and Wunsch algonthm for global alignment

8. a) Define Mulnple sequence alignment? What is the goal of Multiple sequence alignment?
b) Explain simultaneous methods and progressive methods for multiple alignments?